OPIOID-INDUCED CONSTIPATION,
OR OIC, IS DIFFERENT FROM OTHER
TYPES OF CONSTIPATION.

It may require a medicine specifically designed to treat the underlying cause.

Find out more

Learn more about Opioid-Induced
Constipation (OIC)

TAKING OPIOID PAIN TAKING OPIOID PAIN
TAKING OPIOID PAIN
MEDICATIONS FOR
CHRONIC PAIN?
See some examples
CONSTIPATED? CONSTIPATED?
CONSTIPATED?
Symptoms of OIC
FEEL YOU TRIED IT ALL FEEL YOU TRIED IT ALL
FEEL YOU TRIED IT ALL?
See why routine constipation treatments may not work for everyone with OIC
OIC Logo

Opioid-Induced Constipation (OIC) is a
different type of constipation

Opioid treatment can help relieve moderate to severe pain. Unfortunately, opioid use often comes with the undesired effect of constipation. If you’re taking opioid pain medication and experiencing difficulty with bowel movements, speak with your doctor. You may have OIC. 

feel you tired circle
Patients representing treatment options Patients representing treatment options

Like other OIC sufferers, you may have already tried over-the-counter laxatives, diet changes, and exercise.
The truth is, OIC is a unique type of constipation that may require a medicine specifically designed to treat the underlying cause.

Learn more

RELISTOR –
DESIGNED FOR OIC.
DEMONSTRATED
RELIEF.

Get to know RELISTOR

RELISTOR is specifically designed to target the constipating effect opioids have in the gut.

Take action

RELISTOR TABLETS

Checkmark
May increase the
number of bowel
movements per week.*,†,‡,§
May work in as quickly as
4 hours.*,†,‡
Take action
See how RELISTOR works

* Individual results may vary.

† Based on a clinical study of 401 adult patients with opioid-induced constipation (OIC) and long-lasting (chronic) non-cancer pain treated with RELISTOR tablets or placebo (sugar pill).

‡ Based on a clinical study of 312 adult patients with OIC and long-lasting (chronic) non-cancer pain treated with RELISTOR injection or placebo injection.

§ In clinical studies, a spontaneous bowel movement was defined as a bowel movement without the use of a laxative in the previous 24 hours.

OIC seen

how Relistor works

RELISTOR works differently from over-the-counter (OTC) laxatives. It’s an FDA-approved prescription medication for opioid-induced constipation specifically designed to target the constipating effect opioids have in the gut, without impacting opioid pain relief in the central nervous system. Tell your doctor if you experience any changes in your pain relief. 

See how
 
 

Opioids relieve pain by attaching to proteins called receptors, which are located in the brain, spinal cord, and other parts of your body. When this happens, the opioids block pain messages sent from the body through the spinal cord to the brain.

Opioids may attach to those receptors in your gut, which can cause constipation.

RELISTOR is designed to target the constipating effect opioids can have on the gut.

This can help:

  • Move fluid and waste through the bowels
  • Restore fluid movement into the bowels
  • Keep fluid in the bowels
  • Result in a more regular gut

Oh, I See
How To
Save Money
On Relistor

In 2020, 89% of eligible
commercial patients who filled
their prescription and used the
copay card paid $0.

Learn more
Terms and conditions apply. Click here for details.

Eligible patients
may pay as little as
$0 with a copay
card

0* Copay
Terms and conditions apply. Click here for details.
Doctor speaking with patient about OIC symptoms

Talk about your OIC symptoms

Challenge OIC

Talk about your symptoms with your healthcare provider to find out how RELISTOR may help manage your OIC.

RELISTOR® is for adult patients with opioid-induced constipation (OIC) and chronic non-cancer pain.

INDICATIONS

RELISTOR® (methylnaltrexone bromide) is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids.

  • RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.
  • RELISTOR injection is also used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care.

It is not known if RELISTOR is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take RELISTOR if you have a bowel blockage (called an intestinal obstruction) or have a history of bowel blockage.

RELISTOR can cause serious side effects, including:

  • Tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that is severe, does not go away, or gets worse, stop taking RELISTOR and get emergency medical help right away.
  • Diarrhea that is severe or that will not go away. Stop using RELISTOR and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with RELISTOR.
  • Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with RELISTOR including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.

Before you start taking RELISTOR, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney problems.
  • have liver problems.
  • have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • are pregnant or plan to become pregnant. Taking RELISTOR during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with RELISTOR.
  • are breastfeeding or plan to breastfeed. It is not known if RELISTOR passes into your breast milk. Taking RELISTOR while you are breastfeeding may cause opioid withdrawal in your baby. You should not breastfeed during treatment with RELISTOR.

Also, tell your healthcare provider about all of the medicines you take, including prescription and over the-counter medicines, vitamins, and herbal supplements.

The most common side effects of RELISTOR tablets in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, diarrhea, headache, swelling or a feeling of fullness or pressure in your abdomen, sweating, anxiety, muscle spasms, runny nose, and chills.

The most common side effects of RELISTOR injection in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.

The most common side effects of RELISTOR injection in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please see Important Safety Information throughout and click here for full Prescribing Information.

INDICATIONS

RELISTOR® (methylnaltrexone bromide) is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids.

  • RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.
  • RELISTOR injection is also used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care.

It is not known if RELISTOR is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take RELISTOR if you have a bowel blockage (called an intestinal obstruction) or have a history of bowel blockage.

RELISTOR can cause serious side effects, including:

  • Tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that is severe, does not go away, or gets worse, stop taking RELISTOR and get emergency medical help right away.
  • Diarrhea that is severe or that will not go away. Stop using RELISTOR and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with RELISTOR.
  • Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with RELISTOR including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.

Before you start taking RELISTOR, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney problems.
  • have liver problems.
  • have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • are pregnant or plan to become pregnant. Taking RELISTOR during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with RELISTOR.
  • are breastfeeding or plan to breastfeed. It is not known if RELISTOR passes into your breast milk. Taking RELISTOR while you are breastfeeding may cause opioid withdrawal in your baby. You should not breastfeed during treatment with RELISTOR.

Also, tell your healthcare provider about all of the medicines you take, including prescription and over the-counter medicines, vitamins, and herbal supplements.

The most common side effects of RELISTOR tablets in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, diarrhea, headache, swelling or a feeling of fullness or pressure in your abdomen, sweating, anxiety, muscle spasms, runny nose, and chills.

The most common side effects of RELISTOR injection in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.

The most common side effects of RELISTOR injection in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please see Important Safety Information throughout and click here for full Prescribing Information.