Frequently asked questions

RELISTOR is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids:

• RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer
• RELISTOR injection is used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care

It is not known if RELISTOR is safe and effective in children.

RELISTOR helps to keep opioids from attaching to mu-opioid receptors in the gut. RELISTOR works differently from over-the-counter (OTC) laxatives—it is specifically designed to target the effect opioids have in the gut without impacting opioid pain relief.

If you are taking RELISTOR tablets for OIC:

RELISTOR tablets should be taken daily, as directed by your healthcare provider. Even if you do not feel constipated, do not make changes to your medication schedule without talking to your healthcare provider.

Stop taking RELISTOR if you stop taking your prescription opioid pain medicine. Tell your healthcare provider if your pain medicine changes.

• For adults with long-lasting (chronic) non-cancer pain, take 3 tablets, one time each day, with water, in the morning on an empty stomach
  • Take RELISTOR at least 30 minutes before eating your first meal of the day
  • Stop taking laxatives before you start taking RELISTOR tablets. You may use laxatives if RELISTOR does not work after 3 days of treatment
• Your healthcare provider may change your dose if you have kidney or liver problems

If you are taking RELISTOR injection for OIC:

RELISTOR injection should be taken as directed by your healthcare provider. RELISTOR injection is injected under the skin of the upper arm, stomach-area (abdomen), or thigh. Do not inject at the same spot each time (rotate injection sites).

• For adult patients with long-lasting (chronic) non-cancer pain, inject 1 dose of RELISTOR each day
  • Stop taking other laxatives before you start treatment with RELISTOR. You may use other laxatives if RELISTOR does not work after 3 days of treatment
• For adults with advanced illness, inject 1 dose of RELISTOR every other day as needed. You should not inject more than 1 dose of RELISTOR in a 24-hour period

Stop taking RELISTOR if you stop taking your prescription opioid pain medicine. Tell your healthcare provider if your pain medicine changes.

RELISTOR can work quickly. After taking a dose of RELISTOR tablets or injection, you may have a bowel movement within 4 hours.^*,†,‡

In a clinical study of adult patients with advanced illness taking RELISTOR injection, some patients had a bowel movement within 30 minutes.^‡

Individual results may vary.

^*Based on a clinical study of 401 adult patients with OIC and long-lasting (chronic) non-cancer pain treated with RELISTOR tablets or placebo (sugar pill).

^†Based on a clinical study of 312 adult patients with OIC and long-lasting (chronic) non-cancer pain treated with RELISTOR injection or placebo injection.

^‡Based on a clinical study of 133 adult patients with advanced illness and OIC treated with RELISTOR injection or placebo injection.

In a clinical study, the most common side effects in adult patients with long-lasting (chronic) non-cancer pain taking RELISTOR tablets included stomach-area (abdomen) pain (14%), diarrhea (5%), headache (4%), swelling or feeling of fullness or pressure in your stomach (abdomen) (4%), vomiting (3%), sweating (3%), anxiety (2%), muscle spasms (2%), runny nose (2%), and chills (2%).

In a clinical study, the most common side effects of RELISTOR injection in adult patients with long-lasting (chronic) pain that is not caused by cancer included stomach-area (abdomen) pain (21%), nausea (9%), diarrhea (6%), sweating (6%), hot flush (3%), tremor (1%), and chills (1%).

In clinical studies, the most common side effects of RELISTOR injection in adult patients receiving treatment for their advanced illness included stomach-area (abdomen) pain (29%), gas (13%), nausea (12%), dizziness (7%), and diarrhea (6%).

You must activate this savings card before using it by visiting www.RELISTOR.com, calling 1-855-202-3719, or texting SaveNow to 24109. Message and data rates may apply. The full terms and conditions can be viewed at relistor.copaysavingsprogram.com/sms-terms.

Patients without commercial insurance are not eligible. The RELISTOR Savings Program is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. The RELISTOR Savings Program is only good in the USA at participating retail pharmacies. The RELISTOR Savings Program cannot be redeemed at other locations, including government subsidized clinics or facilities. The RELISTOR Savings Program is not valid where otherwise prohibited, taxed, or otherwise restricted. The RELISTOR Savings Program cannot be combined with other offers. The savings card has no cash value. No other purchase is necessary. The savings card is nontransferable. No substitutions are permitted. The savings card is not health insurance. Maximum benefits apply.

Please call 1-855-202-3719 for more information.

The out-of-pocket cost of RELISTOR can vary based on your commercial insurance coverage and pharmacy.

The RELISTOR Savings Program is available for patients with commercial insurance, including commercially insured patients without coverage for RELISTOR.

For eligible patients, Salix Pharmaceuticals will be responsible to cover your co-pay out-of-pocket expense for each eligible prescription fill using this savings card, maximum benefits and other restrictions apply.

Please call 1-855-202-3719 for more information.

Every insurance plan is different. Check with your insurance plan to find out if you have coverage for RELISTOR.