A treatment specifically for OIC
How Does
Relistor
Work?
RELISTOR is an FDA-approved prescription medication specifically for the treatment of opioid-induced constipation (OIC) in adults with long-lasting (chronic) pain.
Watch the video to learn more about how RELISTOR works
Get to know RELISTOR
RELISTOR MAY HELP YOU GET BACK
TO A MORE REGULAR BOWEL ROUTINE
Available in two different formulations: tablets or a subcutaneous injection.
Tablets
For adult patients with opioid-induced constipation (OIC) and long-lasting (chronic) non-cancer pain.
RELISTOR may help increase the number of bowel movements you have each week*
In a clinical study, 52% of adult patients treated with RELISTOR for 4 weeks had at least 3 spontaneous bowel movements (SBMs) per week vs. 38% taking placebo. Individual results may vary.
RELISTOR may work in as quickly as 4 hours*
In the same clinical study, 24% of adult patients treated with RELISTOR had an SBM within 4 hours of the first 450 mg dose vs. 8% taking placebo. Individual results may vary.
*Based on a clinical study of 401 adult patients with opioid-induced constipation (OIC) and long-lasting (chronic) non-cancer pain treated with RELISTOR 450mg tablets or placebo (sugar pill).
Subcutaneous Injection
For adult patients with OIC and advanced illness or pain caused by active cancer and who need opioid dosage increases for comfort care.
For adult patients with OIC and long-lasting (chronic) non-cancer pain.
RELISTOR injection may help increase the number of bowel movements per week†, ‡
In a clinical study, 59% of adult patients with OIC and long-lasting (chronic) pain that is not caused by active cancer treated with RELISTOR injection had at least 3 rescue-free bowel movements (RFBMs)* per week vs 38% taking placebo. Individual results may vary.
RELISTOR injection may work in as quickly as 4 hours†, ‡
In a clinical study, 33% of adults patients with OIC and long-lasting (chronic) pain that is not caused by active cancer treated with RELISTOR injection had a RFBM* within 4 hours of the first 12 mg dose vs 10% taking placebo. Individual results may vary
In another clinical study, 62% of patients with OIC and advanced illness treated with RELISTOR injection experienced an RFBM within 4 hours of first dose vs 14% taking placebo. Individual results may vary
Some patients with OIC and advanced illness may have a bowel movement as quickly as 30 minutes‡
Individual results may vary.
*In clinical studies, a spontaneous bowel movement was defined as a bowel movement that occurred without the use of a laxative in the previous 24 hours.
†Based on a clinical study of 312 adult patients with OIC and long-lasting (chronic) non-cancer pain treated with RELISTOR injection (12 mg once daily) or placebo.
‡ Based on a clinical study of 154 adults patients with OIC and advanced illness treated with RELISTOR injection (0.15 mg/kg or 0.3 mg/kg) or placebo.
Possible Side Effects of RELISTOR
RELISTOR can cause serious side effects, including a tear in your stomach or the wall of your intestine, called a perforation; diarrhea that is severe or does not go away during treatment with RELISTOR; and opioid withdrawal symptoms including sweating, chills, diarrhea, stomach pain, anxiety, and yawning.
Tell your healthcare provider if you have any side effects. These are not all the possible side effects of RELISTOR. You may have others.
In clinical studies, the most common side effects were:
- For RELISTOR tablets in patients with long-lasting (chronic) non-cancer pain: stomach-area (abdomen) pain (14%), diarrhea (5%), headache (4%), swelling/fullness (4%), vomiting (3%), sweating (3%), anxiety (2%), muscle spasms (2%), runny nose (2%), chills (2%)
- For RELISTOR injection in people with long-lasting (chronic) pain not caused by cancer: stomach-area (abdomen) pain (21%), nausea (9%), diarrhea (6%), sweating (6%), hot flush (3%), tremor (1%), chills (1%)
- For RELISTOR injection in people receiving treatment for their advanced illness: stomach-area (abdomen) pain (29%), flatulence (13%), nausea (12%), dizziness (7%), diarrhea (6%)
Formulations and administration
HOW TO
TAKE
RELISTOR
RELISTOR comes in two different formulations – oral tablet and subcutaneous injection. RELISTOR is available for adults with OIC and long-lasting (chronic) non-cancer pain and is designed to help manage your opioid-induced constipation.
RELISTOR injection is also indicated for the treatment of OIC in adults with advanced illness or pain caused by active cancer who require opioid dosage escalation for palliative care.
Tablets
RELISTOR tablets should be taken daily, as directed by your healthcare provider. Even if you do not feel constipated, do not make changes to your medication schedule without talking to your healthcare provider.
Stay close to a toilet after taking RELISTOR.
Stop taking other laxatives before you start taking RELISTOR tablets. You may resume laxatives after 3 days if needed.
Take three 150-mg tablets, for a total of 450 mg each day, in the morning. It is important to take RELISTOR as prescribed by your healthcare provider, which is usually for the duration of your opioid therapy. Your doctor may change your dose if you have kidney or liver problems.
RELISTOR should be taken at least 30 minutes before eating your first meal of the day. Do not eat food right before taking RELISTOR.
Take RELISTOR with water.
Do not use RELISTOR if you have a bowel blockage (intestinal obstruction) or have a history of bowel blockage
Injections
RELISTOR subcutaneous injection should be taken as directed by your healthcare provider and should be kept at room temperature.
RELISTOR injection is injected under the skin of the upper arm, stomach area (abdomen), or thigh. Do not inject at the same spot each time (rotate injection sites).
See the detailed "Instructions for Use" that comes with RELISTOR injection about how to prepare and inject RELISTOR injection, and properly throw away used needles and syringes the right way.
Stay close to a toilet after taking RELISTOR.
For adult OIC patients with long-lasting (chronic) non-cancer pain:
- Inject one dose of RELISTOR under the skin each day.
- Stop taking other laxatives before you start treatment with RELISTOR. You may resume laxatives after 3 days if needed.
For adult OIC patients with advanced illness:
- Inject one dose of RELISTOR under the skin every other day as needed.
- You should not inject more than 1 dose of RELISTOR in a 24-hour period.
RELISTOR injection is the only FDA-approved prescription medication to treat OIC in adult patients with advanced illness (eg, end-stage chronic obstructive pulmonary disease, or COPD; heart disease; Alzheimer’s disease) or pain caused by active cancer and who need increases in their opioid dose for comfort care.