Talk with your doctor about the method that's best for you

The prefilled syringe comes already filled with the dose prescribed by your doctor, so you don't have to worry whether you've put the right amount of RELISTOR into it.

No matter how you take RELISTOR, it is injected just under the skin (a subcutaneous injection); it is not a "deep" or intramuscular (into the muscle) injection.

  • Prefilled syringe

    Picture of a prefilled syringe showing a yellow plunger rod for 8mg dose and dark blue rod for 12mg dose A syringe that comes prefilled with the dose prescribed by your healthcare provider. The prefilled syringe is color-coded, with a yellow plunger rod for an 8-mg dose and a dark blue plunger rod for a 12-mg dose.

    How to use a prefilled syringe

Here are some general questions that patients often ask about RELISTOR.1

For detailed, step-by-step instructions on how to inject RELISTOR, please click on one of the links above that matches the type of syringe that you will be using.

How should I take RELISTOR?

Indication for RELISTOR

RELISTOR® is indicated for the treatment of opioid-induced constipation (OIC) in patients with advanced illness who are receiving palliative care, when response to laxative therapy has not been sufficient. Use of RELISTOR beyond four months has not been studied.

Important Safety Information about RELISTOR

Do not take RELISTOR® (methylnaltrexone bromide) Subcutaneous Injection if you have or may have a blockage in your intestines called a mechanical bowel obstruction. Symptoms of this blockage are vomiting, stomach pain, and swelling of your abdomen. Talk to your healthcare provider if you have any of these symptoms before taking RELISTOR.

Cases of holes or openings in your gastrointestinal (GI) tract have been reported in adult patients with opioid-induced constipation and advanced illness with certain conditions (i.e., cancer, peptic ulcer, Ogilvie's syndrome). These holes or openings have involved varying regions of the GI tract (e.g., stomach or intestines). Use RELISTOR with caution if you have a known or suspected wound or injury to the GI tract. If you get abdominal pain that is severe or will not go away, or nausea or vomiting that is new or worse, stop taking RELISTOR and call your healthcare provider.

If you get diarrhea that is severe or does not stop while taking RELISTOR, stop taking RELISTOR and call your healthcare provider.

Use of RELISTOR beyond four months has not been studied.

Safety and efficacy of RELISTOR have not been established in children.

The most common side effects of RELISTOR in clinical studies include: abdominal (stomach) pain, gas, nausea, dizziness, diarrhea, and sweating.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch/ or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-508-0024
Fax: 1-510-595-8183
Email: customerservice@salix.com

Please see complete Prescribing Information for RELISTOR.