Taking RELISTOR

Talk with your doctor about the method that's best for you

No matter how you take RELISTOR, it is injected just under the skin (a subcutaneous injection); it is not a "deep" or intramuscular (into the muscle) injection.

  • Prefilled syringe


    Picture of a prefilled syringe showing a yellow plunger rod for 8mg dose and dark blue rod for 12mg dose A syringe that comes prefilled with the dose prescribed by your healthcare provider. The prefilled syringe is color-coded, with a yellow plunger rod for an 8-mg dose and a dark blue plunger rod for a 12-mg dose.

    How to use a prefilled syringe

For detailed, step-by-step instructions on how to inject RELISTOR, please click the link above that matches the method prescribed by your doctor.

Please refer to the Prescribing Information and Med Guide for full instructions on how to administer RELISTOR.

Here are some general questions that patients often ask about RELISTOR.

How should I take RELISTOR?
Subcutaneous injection sites on the abdomen, thighs, and arms
  • Take RELISTOR exactly as your healthcare provider tells you.
  • Stay close to a toilet after using RELISTOR.

Where?

  • Take RELISTOR by an injection under the skin (subcutaneous injection) of the upper arm, abdomen, or thigh.

How often?

  • If you use RELISTOR and are being treated for long-lasting (chronic) pain that is not caused by cancer:
    • RELISTOR has been shown to be effective in people who have taken opioid pain medicines for at least 4 weeks to treat long-lasting (chronic) pain not caused by cancer.
    • Stop taking other laxatives before you start treatment with RELISTOR. You may use other laxatives if RELISTOR does not work after 3 days of treatment.
    • Inject 1 dose of RELISTOR each day.
  • If you use RELISTOR and are receiving treatment for advanced illness:
    • Inject 1 dose of RELISTOR every other day, as needed. You should not inject more than 1 dose of RELISTOR in a 24-hour period.

If you stop taking your prescription pain medicine, check with your healthcare provider before continuing RELISTOR. Also, if you take more RELISTOR than prescribed, talk to your healthcare provider right away.

Who should not take RELISTOR?

Do not take RELISTOR if you have or may have a blockage in your intestines called a mechanical bowel obstruction. Symptoms of this blockage are vomiting, stomach pain, and swelling of your abdomen. Talk to your healthcare provider before taking RELISTOR if you have any of these symptoms.

What should I tell my healthcare provider before taking RELISTOR?

Tell your healthcare provider about all of your medical conditions, including if you

  • Have kidney problems.
  • Have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • Are pregnant or plan to become pregnant. Taking RELISTOR during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with RELISTOR.
  • Are breastfeeding or plan to breastfeed. It is not known if RELISTOR passes into your breast milk. Taking RELISTOR while you are breastfeeding may cause opioid withdrawal in your baby. You and your healthcare provider should decide if you will take RELISTOR or breastfeed. You should not do both.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I store RELISTOR?
  • Store RELISTOR vials or prefilled syringes at room temperature between 68°F to 77°F (20°C to 25°C)
  • Do not freeze RELISTOR
  • Keep RELISTOR away from light until you are ready to use it
  • If RELISTOR has been drawn into a syringe and you are unable to use the medicine right away, keep the syringe at room temperature for up to 24 hours. The syringe does not need to be kept away from light during the 24-hour period

Indications

RELISTOR® is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults:

  • with long-lasting (chronic) pain that is not caused by cancer.
  • receiving treatment for advanced illness, when other medicines for constipation have not worked well enough.
    • It is not known if RELISTOR is safe and effective if used for longer than 4 months in people with advanced illness.

Important Safety Information

Do not take RELISTOR® (methylnaltrexone bromide) Subcutaneous Injection if you have or may have a blockage in your intestines (called an intestinal obstruction) or a history of bowel blockage.

RELISTOR can cause serious side effects such as a tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that does not go away, stop taking RELISTOR and get emergency medical help right away.

Stop using RELISTOR and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with RELISTOR.

You may have symptoms of opioid withdrawal during treatment with RELISTOR including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.

Tell your healthcare provider if you have kidney problems or if you have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome. Also, tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Tell your healthcare provider if you are pregnant or plan to become pregnant. Taking RELISTOR during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with RELISTOR. It is not known if RELISTOR passes into your breast milk. Taking RELISTOR while you are breastfeeding may cause opioid withdrawal in your baby. You and your healthcare provider should decide if you will take RELISTOR or breastfeed. You should not do both.

The most common side effects of RELISTOR in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.

The most common side effects of RELISTOR in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-508-0024
Fax: 1-510-595-8183
Email: valeantmc@dlss.com

Click here for full Prescribing Information.

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