Meeting the Challenge of Constipation From Opioid Use

If you or a loved one is living with an advanced illness such as cancer, heart and blood vessel problems (eg, cardiovascular disease), lung problems (eg, emphysema or COPD), or Alzheimer's disease, the doctor may have prescribed an opioid medication.1

Opioids can help alleviate pain. But many patients receiving opioid treatment will probably develop constipation. Your healthcare provider may call this opioid-induced constipation, or OIC. If left untreated, this type of constipation can cause you stomach pain and vomiting, and it may even cause your stools to become large or hard enough to become stuck.1 To avoid side effects such as these, some people may decrease their pain medication (opioids) or even stop taking it—even though they may not get as much relief from pain.2

Only RELISTOR treats the source of constipation from opioid use

RELISTOR works by precisely treating the source of opioid-induced constipation without affecting the pain relief you get from opioid treatment. You and your doctor can continue to manage your pain with opioids to give you relief.

When laxative therapy is not enough to give you relief from constipation from opioid use, you may want to ask your doctor about RELISTOR.

References: 1. RELISTOR® (methylnaltrexone bromide) Prescribing Information, Salix Pharmaceuticals, Inc. 2. Michna E, Blonsky ER, Schulma S, et al. Subcutaneous methylnaltrexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study. J Pain. 2011;12(5):554-562. 1. Emanuel EJ, Emanuel LL. Palliative and end-of-life care. In: Kasper DL, Braunwald E, Fauci AS, et al, eds. Harrison's Principles of Internal Medicine. 16th ed. New York, NY: McGraw-Hill; 2005:53-66. 2. Panchal SJ, Muller-Schwefe P, Wurzelman JI. Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden. Int J Clin Pract. 2007;61(7):1181-1187.