A treatment specifically for OIC

HOW DOES RELISTOR WORK?

About

Relistor is an FDA-approved prescription medication specifically for opioid-induced constipation (OIC) in adults with long-lasting (chronic) pain.

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Relistor can help you get back to a more regular bowel routine

Available in two different formulations; tablets or a subcutaneous injection.

about relistor
about relistor

TABLETS

For adult patients with opioid-induced constipation and long-lasting (chronic) non-cancer pain.

 

Relistor may help increase the number of bowel movements you have each week*

 

Relistor can work quickly. You may have a bowel movement within 4 hours*

Individual results may vary.

*Based on a clinical study of 401 adult patients with opioid-induced constipation (OIC) and long-lasting (chronic) non-cancer pain treated with Relistor tablets or placebo (sugar pill).

subcutaneous injection

For adult patients with opioid-induced constipation and advanced illness or pain cause by active cancer and who need increases in their opioid dose for comfort care.

For adult patients with opioid-induced constipation and long-lasting (chronic) non-cancer pain.

 

Relistor injection may help increase the number of bowel movements you have each week‡†

 

Relistor injection can work quickly. You may have a bowel movement within 4 hours‡†

 

Some patients with OIC and advanced illness who have a bowel movement within 4 hours may do so within 30 minutes‡

Individual results may vary.

†Based on a clinical study of 312 adult patients with OIC and long-lasting (chronic) non-cancer pain treated with Relistor injection or placebo injection.

‡Based on a clinical study of 133 adult patients with advanced illness and OIC treated with Relistor injection or placebo injection.

PossiblE side effects of Relistor

Relistor can cause serious side effects, including a tear in your stomach or the wall of your intestine, called a perforation; diarrhea that is severe or does not go away during treatment with Relistor; and opioid withdrawal symptoms including sweating, chills, diarrhea, stomach pain, anxiety, and yawning.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Relistor. You may have others.

In clinical studies, the most common side effects:

  • in patients with long-lasting (chronic) non-cancer pain taking Relistor tablets included stomach-area (abdomen) pain (14%), diarrhea (5%), headache (4%), swelling or feeling of fullness or pressure in your stomach (abdomen) (4%), vomiting (3%), sweating (3%), anxiety (2%), muscle spasms (2%), runny nose (2%), and chills (2%)
  • of Relistor injection in people with long-lasting (chronic) pain that is not caused by cancer included stomach-area (abdomen) pain (21%), nausea (9%), diarrhea (6%), sweating (6%), hot flush (3%), tremor (1%), and chills (1%)
  • of Relistor injection in people receiving treatment for their advanced illness included stomach-area (abdomen) pain (29%), gas (13%), nausea (12%), dizziness (7%), and diarrhea (6%)
Formulations and Administration

how to take relistor

Relistor comes in two different formulations of oral tablet and subcutaneous injection. Relistor is available for adults with OIC and long-lasting (chronic) non-cancer pain and are designed to help manage your opioid-induced constipation.

TABLETS

 

Relistor tablets should be taken daily, as directed by your healthcare provider. Even if you do not feel constipated, do not make changes to your medication schedule without talking to your healthcare provider.

Stop taking other laxatives before you start taking Relistor tablets. You may resume laxatives after 3 days if needed.

Take three 150-mg tablets, for a total of 450 mg each day, in the morning. Take Relistor only during use of your opioid medication. Your doctor may change your dose if you have kidney or liver problems.

Relistor should be taken at least 30 minutes before eating your first meal of the day. Do not eat food right before taking Relistor.

Take Relistor with a cup of water.

INjections

 

Relistor subcutaneous injection should be taken as directed by your healthcare provider and should be kept at room temperature.

Relistor injection is injected under the skin of the upper arm, stomach-area (abdomen), or thigh. Do not inject at the same spot each time (rotate injection sites).

For adult OIC patients with long-lasting (chronic) non-cancer pain

  • Inject one dose of Relistor subcutaneously each day.
  • Stop taking other laxatives before you start treatment with Relistor. You may resume laxatives after 3 days if needed.

For adult OIC patients with advanced illness

  • Inject one dose of Relistor subcutaneously every other day as needed.
  • You should not inject more than 1 dose of Relistor in a 24-hour period.
  • You may continue regular laxatives as directed.

Relistor injection is the only FDA-approved prescription medication to treat OIC in adult patients with advanced illness (eg, end-stage chronic obstructive pulmonary disease, or COPD; heart disease; Alzheimer's disease) or pain caused by active cancer and who need increases in their opioid dose for comfort care.

Stop taking Relistor if you stop taking your prescription opioid pain medication. Tell your healthcare provider if your pain medication changes.

It's important to take Relistor as prescribed by your healthcare provider

See the FAQs for Relistor
 

Indications

RELISTOR® is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids.

  • RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.
  • RELISTOR injection is also used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care.

It is not known if RELISTOR is safe and effective in children.

Important Safety Information

  • Do not take Relistor if you have a bowel blockage (called an intestinal obstruction) or have a history of bowel blockage.
  • Relistor can cause serious side effects such as a tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that is severe, does not go away, or gets worse, stop taking Relistor and get emergency medical help right away.
  • Stop using Relistor and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with Relistor.
  • You may have symptoms of opioid withdrawal during treatment with Relistor including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.
  • Tell your healthcare provider if you have kidney or liver problems.
  • Tell your healthcare provider if you have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. Taking Relistor during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with Relistor.
  • Taking Relistor while you are breastfeeding may cause opioid withdrawal in your baby. You should not breastfeed during treatment with Relistor. You and your healthcare provider should decide if you will take Relistor or breastfeed. You should not do both.
  • Also, tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • In a clinical study, the most common side effects of Relistor tablets in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, diarrhea, headache, swelling or a feeling of fullness or pressure in your abdomen, sweating, anxiety, muscle spasms, runny nose, and chills.
  • In a clinical study, the most common side effects of Relistor injection in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.
  • In clinical studies, the most common side effects of Relistor injection in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information for RELISTOR tablets and RELISTOR injection, including medication guide.

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Indications - RELISTOR® is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids.

  • RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.
  • RELISTOR injection is also used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care.

It is not known if RELISTOR is safe and effective in children.

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Important Safety Information - Do not take Relistor if you have a bowel blockage (called an intestinal obstruction) or have a history of bowel blockage.

  • Relistor can cause serious side effects such as a tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that is severe, does not go away, or gets worse, stop taking Relistor and get emergency medical help right away.
  • Stop using Relistor and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with Relistor.
  • You may have symptoms of opioid withdrawal during treatment with Relistor including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.
  • Tell your healthcare provider if you have kidney or liver problems.
  • Tell your healthcare provider if you have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. Taking Relistor during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with Relistor.
  • Taking Relistor while you are breastfeeding may cause opioid withdrawal in your baby. You should not breastfeed during treatment with Relistor. You and your healthcare provider should decide if you will take Relistor or breastfeed. You should not do both.
  • Also, tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • In a clinical study, the most common side effects of Relistor tablets in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, diarrhea, headache, swelling or a feeling of fullness or pressure in your abdomen, sweating, anxiety, muscle spasms, runny nose, and chills.
  • In a clinical study, the most common side effects of Relistor injection in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.
  • In clinical studies, the most common side effects of Relistor injection in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information for RELISTOR tablets and RELISTOR injection, including medication guide.

plus icon

Indications

RELISTOR® is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids.

  • RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.
  • RELISTOR injection is also used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care.

It is not known if RELISTOR is safe and effective in children.

Important Safety Information

Do not take Relistor if you have a bowel blockage (called an intestinal obstruction) or have a history of bowel blockage.

  • Relistor can cause serious side effects such as a tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that is severe, does not go away, or gets worse, stop taking Relistor and get emergency medical help right away.
  • Stop using Relistor and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with Relistor.
  • You may have symptoms of opioid withdrawal during treatment with Relistor including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.
  • Tell your healthcare provider if you have kidney or liver problems.
  • Tell your healthcare provider if you have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. Taking Relistor during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with Relistor.
  • Taking Relistor while you are breastfeeding may cause opioid withdrawal in your baby. You should not breastfeed during treatment with Relistor. You and your healthcare provider should decide if you will take Relistor or breastfeed. You should not do both.
  • Also, tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • In a clinical study, the most common side effects of Relistor tablets in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, diarrhea, headache, swelling or a feeling of fullness or pressure in your abdomen, sweating, anxiety, muscle spasms, runny nose, and chills.
  • In a clinical study, the most common side effects of Relistor injection in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.
  • In clinical studies, the most common side effects of Relistor injection in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information for RELISTOR tablets and RELISTOR injection, including medication guide.